Alternative Test Methods: Validation and Regulatory Status
- Acute Aquatic Toxicity
- Acute Mammalian Oral Toxicity
- Acute Mammalian Inhalation Toxicity
- Acute Mammalian Skin Toxicity
- Biologics (non-vaccine)
- Carcinogenicity
- Chronic/Repeated Dose Toxicity
| Conventional test method | Alternative Test Method | Infor- mation Last Updated | ||||
|---|---|---|---|---|---|---|
| Name & Description | Validation Status | Regulatory Status | Effect or Potential Effect on Animal Use | |||
| Acute Aquatic Toxicity | ||||||
| Fish Acute Toxicity (OECD TG 203) | Upper Threshold Concentration (UTC) Step-Down Approach (a tiered testing strategy to be implemented with OECD TG 203) Description and references |
EU: Endorsed as a valid testing strategy by ESAC | EU: Accepted for the assessment of acute aquatic toxicity for hazard classification (2006) | Reduction (Reduces the number of fish used by 65%) |
April 2009 | |
| Fish Embryo Toxicity (FET) Test Description and references |
OECD: Presently assessing validation | OECD: Draft new Test Guideline | Replacement (relative replacement meaning replacing more sentient animals with animals that current scientific evidence indicates have a lower potential for pain perception) |
April 2009 | ||
List of Abbreviations
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