Alternative Test Methods: Validation and Regulatory Status

Conventional test method Alternative Test Method Infor- mation Last Updated
Name & Description Validation Status Regulatory Status Effect or Potential Effect on Animal Use
Hematotoxicity
Haematotoxicity test for acute neutropenia
(use of a second species)
Colony Forming Unit-Granulocyte/Macrophage (CFU-GM) Assay
Description and references

EU: Validated by ECVAM (2006)

No information

Reduction
(For use in place of a second species in the haematotoxicity test for acute neutropenia;, not a replacement as it relies on the availability of mouse Maximum Tolerated Dose data)

April 2009

List of Abbreviations