Alternative Test Methods: Validation and Regulatory Status
- Acute Aquatic Toxicity
- Acute Mammalian Oral Toxicity
- Acute Mammalian Inhalation Toxicity
- Acute Mammalian Skin Toxicity
- Biologics (non-vaccine)
- Carcinogenicity
- Chronic/Repeated Dose Toxicity
| Conventional test method | Alternative Test Method | Infor- mation Last Updated | ||||
|---|---|---|---|---|---|---|
| Name & Description | Validation Status | Regulatory Status | Effect or Potential Effect on Animal Use | |||
| Phototoxicity | ||||||
In vivo Mammalian Phototoxicity Test |
In Vitro 3T3 Neural Red Uptake (NRU) Phototoxocity Test |
EU: Validated by EU/COLIPA and endorsed as valid by ESAC (1997) |
OECD: TG 432 (2004) EU: Accepted by European Commission as method B.41 in Annex V of EU Council Directive 67/548/EEC. This test must be used to determine phototoxic effects of chemicals, and animal tests are prohibited for this purpose in all EU member states (2000) |
Replacement |
April 2009 | |
List of Abbreviations
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